Retinitis pigmentosa: the role of mRNA

The mouse model shows that the alteration of function of nine mRNA is the basis of more widespread retinal disease in the world

Researchers from Trinity College in Dublin and the Sanger Institute in Cambridge (UK) led by Arpad Palfi and Jane Farrar published on Genome Biology search results with which reveal the role of MicroRNA in retinal diseases, and that could pave the way for new therapies.

The researchers used mice engineered to develop a form of retinitis pigmentosa (RP) similar to human and because of this model has been able to verify the hypothesis of the presence of deficient expression of MicroRNA in the development of the disease.

In particular, they highlighted differences in expression of nine nets of MicroRNA in mutant mice than in mice that are natural. MicroRNA are able to regulate genes implicated in retinal diseases and genes encoding components involved in cell death and intracellular processes. Jane Farrar of Trinity College Dublin said "The results of this study suggest that miRNA expression is perturbed during retinal degeneration.

The modulation of expression of retinal MicroRNA represents a possible future treatment for retinopathy such as retinitis pigmentosa "Affecting more than one million people around the world retinitis pigmentosa is the most common inherited form of retinal degeneration caused by progressive cell death of photoreceptors up to blindness.

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