Show antiviral response to predict its success


A new method of visualizing the early immune system response to viral infection may help to predict whether the virus could be contained, or eliminated free to spread indicate Qingsheng Li and his colleagues.

This might be useful to test the extent to which potential vaccines against HIV-1 or other viruses manage to block an emerging infection. The outcome of viral infection "is somehow a game of numbers" say the researchers, a race of speed and size of viral spread and immune system response. Li and his colleagues have combined two techniques in animal models of viral infection to visualize the immune response to HIV monkey (SIV) and some strains of the virus of lymphocytic choriomeningitis.

They show that the amplitude and development of the expansion of T lymphocytes directed against the virus may help predict whether the immune response comes to contain or eliminate the viral infection.

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